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. 2013 Jul 8;2013:989837. doi: 10.1155/2013/989837

Table 2.

Associations between HLA class II and leprosy.

Population Study design Sample size Phenotype Serotype, allele, or haplotype Type of association P or Pc Ref.
Japanese Case-control 295LL, 74TL, 110 controls LL/TT
LL		 DR2
DRw9		 Susceptibility
Resistance		 Pc < 0.008  
Pc < 0.0001		 [12]
Thai Case-control 32TT, 32 controls TT DR2
DQw1		 Susceptibility
Susceptibility		 Pc = 0.02  
Pc = 0.008		 [22]
Korean   157LD, 162 controls LD DR1
DR2
DR9
DR4
DRw53
DQw1
DQw3		 Susceptibility
Susceptibility
Susceptibility
Resistance
Resistance
Susceptibility
Resistance		 P = 0.02  
P < 0.0001  
P = 0.02  
P < 0.0001  
P < 0.0001  
P < 0.0001  
P < 0.0001		 [13]
Turkish Case-control 23LL, 27BL, 50 controls LL/BL DR2 Susceptibility P = 0.015 [23]
Asian Indian Case-control 23TT, 16PTB, 19 controls TT DRB1*15:02 Susceptibility P < 0.05 [24]
Indian Case-control 138LD, 237 controls LD DR2
DQw1
DQw7		 Susceptibility
Susceptibility
Susceptibility		 Pc = 0.00031  
Pc = 0.0004  
Pc = 0.00031		 [15]
Case-control 68LL, 237 controls LL DR2
DQw1		 Susceptibility
Susceptibility		 Pc = 0.0063  
Pc = 0.02
Case-control 30BL, 237 controls BL DR9
DQw7		 Susceptibility
Susceptibility		 Pc = 0.04  
Pc = 0.0006
Indian Case-control 28TT, 65LL, 47 controls LL DRB1*15  
DRB1*15:01  
DRB1*07:01  
DRB5*01:01  
DQB1*06:01  
DQA1*01:02  
DQA1*01:03  
DQA1*02:01 		Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility		 P < 0.0001  
P < 0.001  
P < 0.01  
P < 0.001  
P < 0.0001  
P < 0.01  
P < 0.01  
P < 0.01		 [25]
Case-control 28TT, 65LL, 47 controls TT DRB1*15  
DRB1*15:02  
DQB1*0601  
DQB1*05:03 		Susceptibility
Susceptibility
Susceptibility
Resistance		 P < 0.01  
P < 0.05  
P < 0.01  
P < 0.01
Indian Case-control 39TT, 20PTB, 46 controls TT DRB1*15:02  
Haplotype:
DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0502 		Susceptibility
Resistance 		P < 0.05  
P < 0.05  		 [26]
Indian Case-control 54TT, 44 controls TT DRB1*15 Susceptibility Pc = 0.0063 [27]
Japanese Case-control 38LL/BL, 79LD, 50 controls BL/LL
LD		 DRB1*02  
DRB1*12 		Susceptibility
Resistance		 P = 0.037  
P = 0.013		 [28]
Brazilian Case-control 32TT, 147 controls TT DR2 Susceptibility Pc = 0.0132 [29]
Japanese Case-control 93LD, 114 controls LD DRB1*04:05  
DQA1*03  
DQB1*04:01 		Resistance
Resistance
Resistance		 Pc < 0.05  
Pc < 0.05  
Pc < 0.05		 [30]
Brazilian TDT 73 families (147 sib-pairs) LD DQB1*02:01  
DQB1*05:01  
DRB1*7 		Resistance
Susceptibility
Resistance		 Pc = 0.008  
Pc = 0.008  
Pc = 0.036		 [31]
TDT 73 families (147 sib-pairs) TT DQB1*02:01  
DQB1*05:01 		Resistance
Susceptibility		 Pc = 0.024  
Pc = 0.024
Egyptian Case-control 24LD, 30 controls LD DR2
DQ1		 Susceptibility
Susceptibility		 P = 0.032  
P = 0.015		 [32]
Southern Indian TDT 223 ASP TT DRB1*15(2)  
DRB1*09 		Susceptibility
Resistance		 P = 0.012  
P = 0.004		 [33]
Argentinean Case-control 70LL, 112 controls LL DQB1*02:01  
DQB1*02:02  
DQB1*02:03 		Resistance Pc = 0.02 [34]
Case-control 19PB, 112 controls TT DRB1*04 Resistance Pc = 0.0192
North Indian Case-control 34BT/TT, 79BL/LL, 111 controls BL/LL DRB1*15:01 Susceptibility P < 0.05 [35]
Brazilian Case-control 578LD, 691 controls LD DRB1*04  
DRB1*07  
DRB1*10  
DRB1*12  
DRB1*15 		Resistance
Resistance
Susceptibility
Resistance
Susceptibility		 Pc = 0.04076  
Pc = 0.04753  
Pc = 0.02102  
Pc = 0.04399  
Pc = 0.02288		 [36]
Euro-Brazilian Case-control 578LD, 691 controls LD DRB1*04/NNc  
DRB1*07/NNc 		Resistance
Resistance		 Pc = 0.01  
Pc = 0.01
Afro-Brazilian Case-control 578LD, 691 controls LD DRB1*10/NNc  
DRB1*15/NNc 		Susceptibility
Susceptibility		 Pc = 0.024  
Pc = 0.0002
Vietnam TDT 194 single-case families LD DRB1*10  
DRB1*04 		Susceptibility
Resistance		 Pc = 0.04  
Pc = 0.03
Argentinean Case-control 71LD, 81 controls LD DRB1*14:01  
DRB1*14:06  
DRB1*08:08  
DRB1*11:03 		Susceptibility
Susceptibility
Resistance
Resistance		 Pc = 0.0011  
Pc = 0.0011  
Pc = 0.0006  
Pc = 0.0004		 [37]
Chinese Case-control 305LD, 527 controls LD DRB1*15  
DRB1*09 		Susceptibility
Resistance		 Pc = 0.002  
Pc = <0.001		 [38]
Brazilian Case-control 30BL, 178 controls BL DRB1*16:01 Susceptibility Pc = 0.0208 [39]
Case-control 63LL, 43TT LL DRB1*08 Susceptibility Pc = 0.0481
Taiwanese Case-control 65LD 190 controls ML DRB1*04:05 Resistance Pc = <0.0001 [40]
Brazilian Case-control 17LL, 77 control LL DRB1*11 Resistance Pc = 0.0132 [41]
Brazilian Case-control 36LL, 85 control LL DRB1*16 Susceptibility Pc = 0.0105 [42]
Case-control 20TT, 85 control TT DRB1*14 Susceptibility Pc = 0.032

MB: multibacillary leprosy; PB: paucibacillary; LL: lepromatous leprosy; BL: borderline lepromatous; BB: borderline borderline; TT: tuberculoid leprosy; PTB: pulmonary tuberculosis; LD: leprosy disease; NNc: all not significantly different alleles collapsed into a unique group (i.e., DRB1*04, 07, 10, 12, and 15) [36]; ASP: affected sib-pair; ns: not significant; Pc: corrected P value; Ref.: reference.

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