Table 3.
CTLA-4 +49 A/G and −318 C/T genotype and allele distribution in tumor tissue of NSCLC patients in comparison with the control group.
| CTLA-4 genotypes and alleles | NSCLC patients n = 71 |
Healthy controls n = 104 |
OR (CI 95%) | P value | ||
|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||
| +49 AA | 19 | 0.27 | 49 | 0.47 | 0.41 (0.21–0.78) | 0.02 |
| +49 AG | 25 | 0.35 | 33 | 0.32 | 1.16 (0.62–2.21) | 0.74 |
| +49 GG | 27 | 0.38 | 22 | 0.21 | 2.23 (1.17–4.48) | 0.015 |
|
| ||||||
| χ 2 = 5.83 P = 0.63 | χ 2 = 2.41 P = 0.83 | |||||
|
| ||||||
| +49 A allele | 63 | 0.44 | 131 | 0.63 | 0.47 (0.30–0.72) | 0.028 |
| +49 G allele | 79 | 0.56 | 77 | 0.37 | 2.13 (1.38–3.29) | 0.028 |
| −318 CC | 24 | 0.33 | 36 | 0.34 | 0.96 (0.91–1.82) | 0.15 |
| −318 CT | 19 | 0.27 | 37 | 0.36 | 0.66 (0.34–1.28) | 0.97 |
| −318 TT | 28 | 0.40 | 31 | 0.30 | 1.53 (0.81–2.89) | 0.41 |
|
| ||||||
| χ 2 = 3.42 P = 0.37 | χ 2 = 8.55 P = 0.42 | |||||
|
| ||||||
| −318 C allele | 67 | 0.47 | 109 | 0.60 | 0.81 (0.53–1.24) | 0.32 |
| −318 T allele | 75 | 0.53 | 99 | 0.40 | 1.23 (1.80–1.89) | 0.32 |