Table 4.
CTLA-4 +49 A/G and −318 C/T genotype and allele distribution in blood samples of NSCLC patients in comparison with the control group.
| CTLA-4 genotypes and alleles | NSCLC patients n = 71 | Healthy controls n = 104 | OR (CI 95%) | P value | ||
|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||
| +49 AA | 56 | 0.80 | 49 | 0.47 | 4.19 (2.11–8.33) | 0.58 |
| +49 AG | 13 | 0.18 | 33 | 0.32 | 0.48 (0.23–1.02) | 0.23 |
| +49 GG | 2 | 0.02 | 22 | 0.21 | 0.11 (0.02–0.48) | 0.03 |
|
| ||||||
| χ 2 = 1.23 P = 0.73 | χ 2 = 3.26 P = 0.37 | |||||
|
| ||||||
| +49 A allele | 63 | 0.88 | 131 | 0.63 | 4.32 (2.42–7.72) | 0.47 |
| +49 G allele | 79 | 0.12 | 77 | 0.37 | 0.23 (0.13–0.41) | 0.47 |
| −318 CC | 59 | 0.83 | 36 | 0.34 | 9.29 (0.42–9.48) | 0.76 |
| −318 CT | 10 | 0.14 | 37 | 0.36 | 0.30 (0.14–2.65) | 0.57 |
| −318 TT | 2 | 0.03 | 31 | 0.30 | 0.10 (0.02–0.30) | 0.02 |
|
| ||||||
| χ 2 = 2.67 P = 0.25 | χ 2 = 4.65 P = 0.35 | |||||
|
| ||||||
| −318 C allele | 128 | 0.90 | 109 | 0.60 | 8.30 (0.5–15.36) | 0.23 |
| −318 T allele | 14 | 0.10 | 99 | 0.40 | 0.12 (0.65–2.22) | 0.23 |