Table 2.
Synopsis of broadly anti-HCV/E2 neutralizing mAbs.
| mAb | Origin | Epitope | Genotype breadth of neutralization (HCVpp) | Genotype breadth of neutralization (HCVcc) | In vivo tested | Escape generation | References |
|---|---|---|---|---|---|---|---|
| 9/27 | Rat | Linear | 1a | 1a, 2a | No | N.D. | [3, 28, 32] |
| HCV-AB68 | Human | Conformational | 1b | N.D. | Yes | Yes | [33] |
| AP33 (MRCT10.v362) | Murine (humanized) | Linear | 1–6 | 1a, 2a | Yes | Yes | [34–36] |
| 3/11 | Rat | Linear | 1, 2, 4, 5, 6 | 1a, 2a | No | N.D. | [3, 28] |
| 2/69a | Rat | Conformational | 1a, 2a | 1a | No | N.D. | [3, 28, 37] |
| 11/20 | Rat | Conformational | 1 | N.D. | No | N.D. | [3, 28] |
| 1/39 | Rat | Conformational | 1 | N.D. | No | N.D. | |
| H77.16 | Murine | Conformational | N.D. | 1a | No | N.D. | [38] |
| H77.39 | Murine | Conformational | N.D. | 1a | No | N.D. | |
| J6.36 | Murine | Conformational | N.D. | 2a | No | N.D. | |
| J6.103 | Murine | Conformational | N.D. | 2a | No | N.D. | |
| HCV1 | Human | Linear | 1a, 1b, 2b, 3a, 4a | 2a | Yes | Yes | [39] |
| #8 | Murine | Conformational | N.D. | 1a | No | N.D. | [40, 41] |
| HC-1 | Human | Conformational | 1a, 1b | 2a | No | No | [42] |
| HC-11 | Human | Conformational | N.D. | 2a | No | Yes | |
| CBH-5 | Human | Conformational | 1–6 | 2a, 2b | No | N.D. | [43, 44] |
| CBH-7 | Human | Conformational | 1, 2, 4 | 2a, 2b | No | N.D. | |
| A8 | Human | Conformational | 1–6 | 2a | No | N.D. | [45] |
| 1:7 | Human | Conformational | 1–6 | 2a | No | N.D. | |
| AR2A | Human | Conformational | 1a, 2a, 2b, 4, 5 | No | No | N.D. | [46] |
| AR3A | Human | Conformational | 1–6 | 1–6 | Yes | N.D. | [26, 46] |
| AR3B | Human | Conformational | 1a, 1b, 2a, 2b, 4, 5 | 2a | Yes | N.D. | [46] |
| AR3C | Human | Conformational | 1a, 1b, 2a, 2b, 4, 5 | 2a | No | N.D. | |
| AR3D | Human | Conformational | 1a, 1b, 2a, 2b, 4, 5 | 2a | No | N.D. | |
| AR4A | Human | Conformational | 1–6 | 1–6 | Yes | N.D. | [26] |
| AR5A | Human | Conformational | 1a, 1b, 4, 5, 6 | 1a, 2a, 4, 5, 6 | No | ND | |
| HC33.1 | Human | Linear | N.D. | 1a–6a | No | N.D. | [47] |
| HC33.4 | Human | Linear | N.D. | 1a–6a | No | N.D. | |
| HC33.8 | Human | Linear | N.D. | 1a, 2a, 4a | No | N.D. | |
| HC33.29 | Human | Linear | N.D. | 1a, 2a, 4a | No | N.D. | |
| mu5B3 (hu5B3.v3) | Murine (humanized) | Linear | 1a, 1b, 2a | 2a | No | Yes | [36] |
| HC84-1 | Human | Conformational | 1a | 1a–6a | No | No | [48] |
| HC84-27 | Human | Conformational | 1a | 1a–6a | No | No | |
| e20 | Human | Conformational | 1a, 1b, 2a, 2b, 4, 5 (N.D. on 3 and 6) | 1a, 2a | No | N.D. | [49–51] |
| e137 | Human | Conformational | 1a, 1b, 2a, 2b, 4, 5 (N.D. on 3 and 6) | 1a, 2a | No | N.D. | [50–52] |
ND: not determined.