Table 4.
Frequency of genotypes (%) of tumour necrosis factor (TNF)-α,interleukin (IL)-10 and IL-6 polymorphisms in patients with and without acute kidney injury (AKI) according disease category at intensive care unit (ICU) admission
| With AKI* | Without AKI* | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| (n = 139) | (n = 164) | ||||||||
| Disease category | Clinical | Surgical | Sepsis | Other | Clinical | Surgical | Sepsis | Other | |
| TNF-α (−308 G>A)* | |||||||||
| Low producer | GG | 23 (16%) | 3 (2%) | 47 (34%) | 3 (2%) | 31 (19%) | 12 (7%) | 50 (30%) | 9 (5%) |
| High producer | GA | 18 (13%) | 5 (4%) | 35 (25%) | 2 (2%) | 19 (11%) | 4 (2%) | 23 (14%) | 6 (3%) |
| AA | 1 (1%) | 0 | 1 (1%) | 1 (1%) | 2 (1%) | 2 (1%) | 6 (3%) | – | |
| With AKI | Without AKI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| (n = 136) | (n = 162) | ||||||||
| Disease category | Clinical | Surgical | Sepsis | Other | Clinical | Surgical | Sepsis | Other | |
| IL-10 (−1082 G>A)* | |||||||||
| Low producer | AA | 18 (13%) | 0 | 25 (13%) | 1 (1%) | 19 (12%) | 5 (3%) | 35 (21%) | 5 (3%) |
| Intermediate producer | GA | 20 (15%) | 7 (5%) | 50 (36%) | 4 (4%) | 27 (16%) | 12 (7%) | 40 (25%) | 9 (5%) |
| High producer | GG | 5 (4%) | 0 | 7 (5%) | 1 (1%) | 6 (3%) | 1 (1%) | 3 (2%) | 1 (2%) |
| With AKI | Without AKI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| (n = 126) | (n = 138) | ||||||||
| Disease category | Clinical | Surgical | Sepsis | Other | Clinical | Surgical | Sepsis | Other | |
| IL-6 (−174 G>C)* | |||||||||
| Low producer CC | 12 (9%) | 1 (10%) | 18 (1%) | 1 (1%) | 13 (9%) | 5 (4%) | 13 (9%) | 2 (2%) | |
| High producer | GC | 8 (6%) | 2 (18%) | 21 (16%) | 3 (2%) | 13 (9%) | 6 (4%) | 16 (11%) | 5 (4%) |
| GG | 17 (13%) | 4 (17%) | 37 (29%) | 2 (1%) | 19 (14%) | 4 (3%) | 35 (25%) | 7 (5%) | |
*
No statistical differences between groups; P > 0·05.