Table 2. Evolving facial features present in late infancy/preschool age and in late childhood/adolescence in CS patients.

	Late infancy/preschool	Late childhood/adolescence
Head shape	Postnatal microcephaly	Microcephaly, tendency to turricephaly
Face shape	Square and hypotonic with micrognathia and full cheeks	Elongated
Neck	Short	Without significant particularity
Eyes	Type 1: marked epicanthic folds and downward-slanting, high-arched palpebral fissures with frequent unilateral or bilateral ptosis Type 2: elongated, wave-shaped palpebral fissures with long, thick eyelashes	Downward-slanting and wave-shaped palpebral fissures
Ears	Long ears with an everted upper part of the auricle and/or a prominent lobe	No special features
Hair	No special features	Thick hair and low hairline
Nose	No special features	Prominent beak-shaped nose with a high nasal bridge
Philtrum and mouth	Relatively short philtrum; small, open mouth with downturned corners, thick lower lip and marked mentolabial sulcus	Short philtrum upturned and associated with maxillary prognathia; open mouth expression and appearance of prominent central incisors
Smile	No special features	Grimacing smile

Abbreviation: CS, Cohen syndrome.