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Effect of i.p. sodium bicarbonate administration on MMP activity-related fluorescence in mouse xenografts. MMP activity in tumor bearing mice expressed as a percentage of the fluorescence taken prior to injecting 1 mL of 1 M sodium bicarbonate (n = 5) or PBS (n = 3). The mean change in fluorescence 1 hour after injection of sodium bicarbonate was statistically significant (*P < 0.0001). (b) Representative images comparing a PBS-treated mouse to a sodium bicarbonate-treated mouse.
