Table 1.

Master Regulators of TGF-β-induced EMT

Transcriptional Regulators	Gene target
Twist	Snail-2, TGF-β (Taube et al. 2010)
Snail	E-cad (Cano et al. 2000), ER-α (Dhasarathy, et al., 2007)
HMG2a	Snail-1, Snail-2, Twist (Thuault et al. 2006)
Snail-2	E-cad (Hajra, et al., 2002)
Zeb1/2	E-cad (Comijn, et al., 2001)
Dnmt1	E-cad (Papageorgis et al. 2010)
Six1	TβR-I (Micalizzi et al., 2010b)
FOXC2	Vim*, Fibro*, α-SMA*, N-Cad (Mani, et al., 2007)
MicroRNA	Transcript target
miR-200c	ZEB1, ZEB2 (Gregory et al. 2008)
miR-9	E-cad (Ma et al. 2010)
miR-155	RhoA (Kong et al. 2008)
miR-21	Tiam1 (Cottonham et al. 2010, Davis et al. 2008 Zavadil et al. 2007)

^*α-Smooth muscle actin; Fibronectin; Vimentin