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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Gastroenterology. 2013 Mar 22;144(5):873–876. doi: 10.1053/j.gastro.2013.03.016

Fig. 1.

Fig. 1

Mesenchymal FoxF2 regulates intestinal epithelial proliferation and modulates adenoma initiation and growth in Apcmin/+ mice. Epithelial-mesenchymal cross-talk plays a critical role in crypt-villus morphogenesis. Hedgehog signals to mesenchyme. Bmps and FoxF1/F2 are key mesenchymal factors that crosstalk to epithelium. Reduced FoxF1/F2 expression results in increased proliferation and increased Wnt signaling during villus morphogenesis (bottom left), and FoxF2 gene dosage of regulates adenoma initiation and growth (top right).