Table 2.
Protein domains of NF-E2-related factor 2.
| Domains | Amino acid positions* | Predicted functions | |
|---|---|---|---|
| Human (605 aa) | Mouse (597 aa) | ||
| Neh2 | 16–89 DLG motif 17–32, ETGF motif 77–82 |
16–89 | KEAP1 repression through DLG/ETGF motif-DC motif binding, fast, redox-sensitive proteasomal degradation. |
| Neh4 | 111–134 | 111–134 | Translocation and transactivation. Phosphorylation or CBP binding. |
| Neh5 | 182–209 | 172–201 | |
| Neh6 | 337–394 (or 338–388) |
328–385 | Degron motif-associated constitutive turnover, slow, redox-insensitive (Keap1-independent). |
| Neh1 | 435–568 basic motif 503–518 leucine zipper 525–539 |
427–560 basic motif 494–509 leucine zipper 517–531 |
Dimerization for nuclear translocation, DNA binding through basic motif-leucine zipper. |
| Neh3 | 569–605 | 561–597 | CHD6 binding, stability, or transactivation. |
*Varies slightly among publications.