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Flank xenograft growth by caliper measurement and BLI. U87-Luc flank xenografts were measured by calipers (a) and BLI (b) twice per week for 3 weeks. The tumors were allowed to achieve a large size to create central hypoxia. The tumors were segregated into upper, middle, and lower tertiles based on their BLS on day 17. For each tertile group, the average BLS on day 21 relative to day 17 was quantified as a fold change (c).
