Table 1.
Methylation-Specific MLPA Probe Panel (ME001)
| # | Gene probe | Chrom Loc |
|---|---|---|
| 1 | TP73 | 01p36 |
| 2 | CASP8 | 02q22.3 |
| 3 | VHL | 03p25.3 |
| 4 | RARB | 03p24 |
| 5 | *MLH1 | 03p21.1 |
| 6 | MLH1 | 03p21.1 |
| CTNNB1 | 03p22 | |
| 7 | *RASSF1 | 03p21.3 |
| 8 | RASSF1 | 03p21.3 |
| 9 | FHIT | 03p14.2 |
| CASR | 03q21 | |
| 10 | APC | 05q21 |
| 11 | ESR1 | 06q25.1 |
| PARK2 | 06q26 | |
| CDK6 | 07q21.3 | |
| 12 | CDKN2A | 09p21 |
| 13 | CDKN2B | 09p21 |
| 14 | DAPK1 | 09q34.1 |
| AI651963 | 10p14 | |
| CREM | 10p12.1 | |
| 15 | PTEN | 10q23.3 |
| 16 | CD44 | 11p12 |
| 17 | GSTP1 | 11q13 |
| 18 | ATM | 11q23 |
| 19 | IGSF4 | 11q23 |
| TNFRSF1A | 12p13 | |
| TNFRSF7 | 12p13 | |
| 20 | CDKN1B | 12q13.1 |
| PAH | 12q23 | |
| 21 | CHFR | 12q24.33 |
| 22 | BRCA2 | 13q12.3 |
| BRCA2 | 13q12.3 | |
| MLH3 | 14q24.3 | |
| TSC2 | 16p13.3 | |
| CDH1 | 16q22.1 | |
| 23 | CDH13 | 16q24.2 |
| 24 | HIC1 | 17p13.3 |
| 25 | BRCA1 | 17q21 |
| BCL2 | 18q21.3 | |
| KLK3 | 19q13 | |
| 26 | TIMP3 | 22q12.3 |
Bolded=probes with HhaI site (n=26 probes);
*
genes with multiple probes in the promoter region