Table 3.

Case Summary and Methylation Status

	Patient No.
	1a	2a	3a	4a	5a	6c	7b	8a	9a	10a	11b	12b	13b	14a	15a
No. of biopsies	7	6	2	6	4	2	4	2	2	3	3	3	5	2	2
TIMP3d							M			M	M	M	M
APCd			M	M	M		M	M					M	M	M
CDKN2Ad					M		M				M	M		M
MLH1					M		M
KLK10										M		M			M
MEN1				M
CDKN2Bd		M		M	M		M			M	M	M	M
VHLd			M	M							M	M	M
TP73				M							M		M
FANCD26				M
BRCA2	M			M
IGSF4				M			M
RASSF1														M
DAPK1d				M					M			M	M
HIC1d				M	M			M			M
ESR1		M										M
CDKN1B										M
BRCA1									M	M
GSTP1d				M	M		M		M

Abbreviation: M, methylated.

^aCases with dissimilar epigenetic events in multiple biopsy specimens.

^bCases with similar epigenetic events in multiple biopsy specimens.

^cCase with absence of M genes.

^dCommonly M genes (present in >3 cases).