Table 3.
| Clinical symptoms | rhTSH | Hypothyroidism | ||
|---|---|---|---|---|
| Points per symptom | Avrg. points per symptom and patient | Points per symptom | Avrg. points per symptom and patient | |
| Gain in weight | 6 | 0.27 | 14 | 0.74 |
| Fatigue/lethargy | 9 | 0.41 | 33 | 1.65 |
| Laps of concentration | 5 | 0.23 | 20 | 1.00 |
| Disorder of sleep/insomnia | 10 | 0.45 | 14 | 0.70 |
| Intolerance to cold | 9 | 0.41 | 16 | 0.80 |
| Constipation | 5 | 0.23 | 15 | 0.75 |
| Cold skin | 1 | 0.05 | 10 | 0.53 |
| Rough skin | 5 | 0.25 | 17 | 0.94 |
| Slowed movements | 6 | 0.30 | 13 | 0.68 |
| Periorbital edema | 2 | 0.10 | 13 | 0.68 |
| Peripheral edema | 0 | 0.00 | 4 | 0.22 |
|
| ||||
| Avrg. points per symptom, patient, and study arm | 2.42 | 8.45 | ||
|
| ||||
| Mann-Whitney's statistic | 113.0 | |||
| Z statistic | — | |||
| 2-tailed P | 0.0002 (exact tables used, 27% ties) | |||