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Effect of buprenorphine on didanosine in plasma
| Pharmacokinetic parameter | Control | Buprenorphine | p value |
|---|---|---|---|
| AUC0–12 (h ng/ml) | 2,278 (320) | 2,336 (322) | NS |
| Cl/F (L/h) | 298 (126) | 210 (32) | NS |
| Cmax (ng/ml) | 719 (130) | 612 (120) | NS |
| Tmax (h) | 2.5 (1.5–4.0) | 2.5 (1.0–12.0) | NS |
