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. Author manuscript; available in PMC: 2013 Jul 25.
Published in final edited form as: Am J Addict. 2010 Jan-Feb;19(1):17–29. doi: 10.1111/j.1521-0391.2009.00004.x

TABLE 6.

Effect of buprenorphine on tenofovir in plasma

Pharmacokinetic parameter Control Buprenorphine p value
AUC0–12 (h ng/ml) 3,039 (385) 3,080 (290) NS
Cl/F (L/h) 119 (21) 104 (8) NS
Cmax (ng/ml) 321 (33) 265 (44) NS
Tmax (h) 1.7 (0.5–4.0) 2.0 (0.5–4.0) NS

Note: For pharmacokinetics analyses of the effect of buprenorphine on either didanosine or tenofovir: values are the mean (standard error of the mean) for 10 subjects who participated in both sessions, except that the discontinuous variable, Tmax, is given as median (range). Student's unpaired t-test was used to determine p-values for all parameters except Tmax, where the Wilcoxon test was used.