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. 2013 Jul 25;9(7):e1003139. doi: 10.1371/journal.pcbi.1003139

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© 2013 Lawson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — The first five panels show results from the stochastic model with varying values of 20, 40, 60, 80, 100 (left to right); the final panel shows results from the deterministic model. values (x-axis) range from 0 to 4000, / ratio (y-axis) ranges from 0 to 10. Blue indicates accurate tracking (>70% probability), red indicates narrow width ( FWHM), purple indicates that both criteria are met and white indicates that neither criterion is met. As the number of actin cables is increased, the stochastic phenotype plots converge to the deterministic plot. Lower actin cable number confers a larger region where both criteria are satisfied, indicating that increased stochasticity leads to more robustness to parameter variation. For each plot, the parameter was adjusted to maintain a constant flux of Spa2 to the membrane.

Inline graphic — The first five panels show results from the stochastic model with varying values of 20, 40, 60, 80, 100 (left to right); the final panel shows results from the deterministic model. values (x-axis) range from 0 to 4000, / ratio (y-axis) ranges from 0 to 10. Blue indicates accurate tracking (>70% probability), red indicates narrow width ( FWHM), purple indicates that both criteria are met and white indicates that neither criterion is met. As the number of actin cables is increased, the stochastic phenotype plots converge to the deterministic plot. Lower actin cable number confers a larger region where both criteria are satisfied, indicating that increased stochasticity leads to more robustness to parameter variation. For each plot, the parameter was adjusted to maintain a constant flux of Spa2 to the membrane.