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. 2013 Jul 25;9(7):e1003102. doi: 10.1371/journal.pcbi.1003102

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© 2013 Bains et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In this instance, TCR sensitivity is assumed to increase during development, such that an encounter with the agonist ligand TIM delivers a signal that initiates T development early in selection (phase A) but causes deletion if encountered later (phase B).

Inline graphic — In this instance, TCR sensitivity is assumed to increase during development, such that an encounter with the agonist ligand TIM delivers a signal that initiates T development early in selection (phase A) but causes deletion if encountered later (phase B).