Figure 2.

Post-DBS increases in AS-induced NMD events. A-D: Shown are total numbers of AS events (i), relative frequency of AS events in exons (ii), and overlapping ratio between functional predictions of the changed exons (black denotes no overlap) (iii) that were detected by exon. Exon level analysis of exon array data from (A) whole blood from mixed early-advanced PD patients external cohort and HC volunteers (B) advanced PD patients as compared with control volunteers (C) advanced patients post-DBS on stimulation (PD Stim-ON) as compared with pre-DBS and (D) post-DBS OFF stimulus as compared with one hour earlier ON- stimulus. (E): Total numbers of NMD and truncation AS events detected in each of the tested conditions. Purple: truncation events, orange: NMD, green: both. The NMD events are a subset of the total number of detected AS events that were observed in all of the interrogated microarray probe-sets.