Figure 4.

Post-DBS NMD spliced transcripts correct disease pathways. (A) PD patients’ pre-DBS exhibited functional changes of AS genes enriched in immune system development, ATP-binding, mitochondrion organization, alternative splicing and metal ion transport. NMD/AS genes were enriched in cell cycle checkpoint process. (B) DBS treatment induced functional changes in leukocyte proliferation, ATP-binding, Oxidative phosphorylation, protein transport, mitochondrion outer membrane, alternative splicing, metal ion transport and mitosis. (C) DBS-induced NMD/AS functional enrichment included regulation of protein kinase cascade, cellular response to stress, alternative splicing, DNA damage, DNA repair and disease mutation.