Figure 7.

Comparison of DNA Methylation Levels between the 723-kb Region and Other Genomic Regions.

DNA methylation level, with 1 representing complete methylation, of the 723-kb region on sDic-15 and normal chromosome 9 compared with 1000 randomly selected genomic regions (Rand-1000) and two well-assembled centromere sequences, centromeres 2 and 5 (Cen2 and Cen5). The Rand-1000 regions, each 350 kb in length, were selected randomly from chromosomes 1 to 10. The Cen2 region was defined from 92,200,000 to 95,000,000 bp on chromosome 2, while Cen5 from 102,000,000 to 106,550,000 bp on chromosome 5. The methylation level includes all CpG contexts of selected regions. The dashed line highlights the 75th percentile of the Rand-1000 regions. The x axis represents the different region selected from the chromosome, and the y axis represents the DNA methylation level.

(A) Methylation level including all CpG contexts of selected regions. The dashed line highlights the 75th percentile of the Rand-1000 regions.

(B) CG methylation level. The dashed line highlights the 75th percentile of the Rand-1000 regions.

(C) CHG methylation level. The dashed line highlights the 75th percentile of the Rand-1000 regions.

(D) CHH methylation level. The dashed line highlights the 25th percentile of the Rand-1000 regions.

[See online article for color version of this figure.]