Figure 5. Inhibition of Rev-erb alpha inhibits glucagon secretion and calcium signals in alphaTC1-9 cells and pancreatic alpha-cells.

(A) Glucagon secretion from alphaTC1-9 cells in the presence with 0.5 mM, 11 mM glucose and 10 µM of the Rev-erb alpha antagonist SR8278 (n = 8). (B) Intracellular calcium signals in alphaTC1-9 cells in the presence of 0.5 mM glucose and 10 µM of the Rev-erb alpha antagonist SR8278 (n = 32 cells). (C) Area under the curve calculated from experiment 5B. *p<0.05, **p<0.01. Data are expressed as mean ±S.E.M.