Table 1. Summary of signal patterns observed after FISH of the 8p21- and 8q22-band specific BAC probes, RP11-177H13 and RP11-10G10, respectively, to 54 breast tumor touch preparations.
Case | Histological Type | Grade | Total cells analysed | Nuclei counts | 8q22/8p21 ratio | |||
>2 copies of 8p21 | <2 copies of 8p21 | >2 copies of 8q22 | <2 copies of 8q22 | |||||
BT9 | IDC | 1 | 103 | 0 | 81 | 5 | 2 | 1.68 |
BT38 | IDC | 1 | 202 | 25 | 0 | 25 | 0 | 1.00 |
BT39 | IDC | 1 | 206 | 11 | 1 | 5 | 8 | 0.97 |
BT43 | IDC | 1 | 104 | 3 | 1 | 2 | 25 | 0.88 |
BT45 | IDC | 1 | 100 | 0 | 82 | 0 | 15 | 1.57 |
BT63 | IDC | 1 | 123 | 0 | 14 | 83 | 0 | 2.40 |
BT66 | IDC | 1 | 95 | 53 | 0 | 53 | 0 | 1.00 |
BT67 | IDC | 1 | 216 | 0 | 0 | 5 | 1 | 1.01 |
BT69 | IDC | 1 | 203 | 3 | 0 | 3 | 0 | 1.00 |
BT83 | IDC | 1 | 111 | 103 | 0 | 103 | 0 | 1.00 |
BT207 | IDC | 1 | 63 | 4 | 5 | 62 | 0 | 3.88 |
BT7* | IDC | 2 | 115 | 3 | 46 | 107 | 0 | 3.36 |
BT19 | IDC | 2 | 102 | 98 | 0 | 99 | 0 | 1.03 |
BT44 | IDC | 2 | 211 | 37 | 0 | 34 | 0 | 0.99 |
BT52 | IDC | 2 | 161 | 31 | 0 | 36 | 0 | 1.01 |
BT56* | IDC | 2 | 122 | 1 | 94 | 110 | 0 | 2.66 |
BT68 | IDC | 2 | 154 | 0 | 137 | 8 | 1 | 1.85 |
BT71 | IDC | 2 | 123 | 48 | 1 | 122 | 0 | 3.31 |
BT109 | IDC | 2 | 116 | 94 | 0 | 95 | 0 | 1.06 |
BT146 | IDC | 2 | 102 | 0 | 92 | 2 | 0 | 1.84 |
BT173 | IDC | 2 | 152 | 2 | 0 | 122 | 0 | 3.20 |
BT193 | IDC | 2 | 207 | 2 | 35 | 1 | 5 | 1.08 |
BT208* | IDC | 2 | 111 | 0 | 91 | 107 | 0 | 2.89 |
BT215 | IDC | 2 | 109 | 66 | 0 | 66 | 0 | 1.00 |
BT2 | IDC | 3 | 108 | 59 | 3 | 74 | 1 | 3.35 |
BT5 | IDC | 3 | 102 | 1 | 7 | 65 | 1 | 1.37 |
BT30 | IDC | 3 | 142 | 50 | 48 | 118 | 0 | 3.08 |
BT37* | IDC | 3 | 232 | 0 | 215 | 218 | 4 | 3.16 |
BT40 | IDC | 3 | 111 | 3 | 0 | 109 | 0 | 3.05 |
BT42* | IDC | 3 | 114 | 1 | 98 | 98 | 0 | 2.59 |
BT46 | IDC | 3 | 50 | 2 | 1 | 21 | 3 | 1.24 |
BT47* | IDC | 3 | 104 | 0 | 77 | 89 | 0 | 2.59 |
BT57 | IDC | 3 | 111 | 129 | 2 | 87 | 0 | 1.59 |
BT59 | IDC | 3 | 122 | 1 | 106 | 114 | 0 | 3.52 |
BT61* | IDC | 3 | 128 | 1 | 107 | 115 | 0 | 2.55 |
BT72 | IDC | 3 | 109 | 12 | 4 | 89 | 0 | 3.77 |
BT76 | IDC | 3 | 104 | 4 | 0 | 84 | 0 | 4.76 |
BT78 | IDC | 3 | 206 | 1 | 1 | 5 | 0 | 1.02 |
BT91 | IDC | 3 | 113 | 3 | 0 | 86 | 0 | 1.62 |
BT107 | IDC | 3 | 77 | 19 | 0 | 20 | 2 | 1.07 |
BT108* | IDC | 3 | 102 | 2 | 66 | 50 | 0 | 2.04 |
BT117 | IDC | 3 | 128 | 7 | 36 | 91 | 0 | 2.33 |
BT119* | IDC | 3 | 161 | 0 | 64 | 75 | 0 | 1.62 |
BT120 | IDC | 3 | 109 | 0 | 70 | 82 | 0 | 5.93 |
BT139 | IDC | 3 | 89 | 2 | 0 | 2 | 0 | 1.00 |
BT158 | IDC | 3 | 105 | 5 | 1 | 101 | 0 | 4.64 |
BT182* | IDC | 3 | 130 | 1 | 58 | 109 | 1 | 2.33 |
BT184 | IDC | 3 | 101 | 1 | 0 | 76 | 0 | 1.73 |
BT188 | IDC | 3 | 112 | 0 | 93 | 97 | 0 | 3.95 |
BT190 | IDC | 3 | 102 | 3 | 2 | 4 | 0 | 1.02 |
BT191 | IDC | 3 | 101 | 0 | 0 | 98 | 0 | 1.98 |
BT55 | ILC | 1 | 78 | 0 | 5 | 2 | 76 | 0.57 |
BT124 | ILC | 2 | 151 | 1 | 0 | 1 | 0 | 1.00 |
BT31 | ILC | 3 | 119 | 116 | 0 | 119 | 0 | 1.16 |
Abbreviations: IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma. Cases with likely i(8q) are marked with an asterisk.