Table 3.

Clinical manifestations of cases of ALS-like syndrome associated with HIV infection.

Source	Age/ Gender	Duration of HIV infection (months)	CD4 cell/mm3	HIV load	MND deficit: UMN LMN	El Escorial diagnostic grade	Treatment	Survival (months)	ALS course Remarks
Hoffman et al, 1985	26/M	Newly discovered	Not reported	Not reported	LMN + UMN	Definite	Not reported	>12	Progressive
Sher et al, 1988	30/M	Unknown	Not reported	Not reported	LMN	Probable/possible		3, died	Progressive
Verma et al, 1990	32/M	Newly discovered	CD4/CD8: 0.72	Not reported	LMN + UMN	Probable/possible	Not reported	24, died	Improved, died of infection
Huang et al, 1993	45/M	Newly discovered	397	Not reported	LMN	Suspected	Zidovudine	Unknown	Progressive
Casado et al, 1997	30/M	18	CD4/CD8: 0.76	Not reported	LMN + UMN	“Classical”	Not reported	>16	Progressive
Simpson et al, 1994	45/M	Unknown	560	Not reported	LMN + UMN	Definite	Zidovudine, IVIg, Prednisone	48, died	No improvement
Galassi et al*	22/W	Unknown	438, CD4/CD8: 0.39	Not reported	LMN	Probable/possible	Zidovudine, Methyl- Prednisolone, IVIg	Not available	Deterioration, relapse, improvement
Galassi et al, 1998	30/M	Unknown	340	Not reported	LMN	Suspected	Zidovudine, Zalcitabine, Steroid	3, died	Rapidly Progressive
Sastre-garriga et al, 2000	39/W	Newly discovered	540	22000	LMN	Suspected	Not reported	4,alive	Progressive
MacGowan et al, 2001	32/W	Newly discovered	44	77.9×103 (serum) 61.6 × 103 (CSF)	LMN + UMN	Definite	Zidovudine, Lamivudine, Nelfinavir	>48, alive	Recovered
Moulignier et al, 2001
Patient #1	27/M	Newly discovered	84	Not detected	LMN + UMN	Definite	Zidovudine	6, died	Transiently stabilized
Patient #2	61/M	72	44	Not detected	LMN + UMN	Probable/possible	Zidovudine	26, died	Total recovery
Patient #3	29/M	54	2	Not detected	LMN + UMN	Probable/possible	Zidovudine	14	Subtotal recovery
Patient #4	22/M	6	123	3.7 log10	LMN + UMN	Zidovudine, Didanosine	Probable/possible	35, died	Partial recovery
Patient #5	25/M	28	37	4.9 log10	LMN + UMN	Zidovudine, Lamivudine	Probable/possible	52, alive	Subtotal recovery
Patient #6	40/W	19	227	3.3 log10	LMN + UMN	Zidovudine, Zalcitabine, Indinavir	Probable/possible	>40, alive	Total recovery
Nishio et al, 2001	42/W	108	107	44.5 ×103	LMN	Suspected	Stavudine, Lamivudine, Nelfinavir	>7, alive	Recovered; minimal residual deficit
Zoccolella et al, 2002	44/M	Newly discovered	360	34 ×103	LMN + UMN	“Classical”	Zidovudine, Lamivudine, Nevirapine, Riluzole	36, died	Progressive
Von Giesen et al, 2002	?/M	1	447	21.9 × 103	Not provided	“Classical”	Zidovudine, Lamivudine, Nevirapine	Not available	Deteriorated
Pearl et al, 2003	33/M	192	110	56 × 103	LMN	Suspected	Not reported	1, died	Progressive, died of infection
Sinha et al, 2004	37/M	discovered	170	Not reported	UMN	Probable	Zidovudine, Lamivudine, Nevirapine	>1, alive	Slight improvement
Verma et al, 2006
Patient #1	60/M	132	430	Not detected	LMN + UMN	Definite	Zidovudine, Lamivudine, Saquinavir	13, died	Progressive
Patient #2	59/M	36	394	Not detected	LMN + UMN	Definite	Zidovudine, Lamivudine, Trizivir	76, died	Progressive
Berger et al, 2005	35/M	Newly discovered	244	8.3 ×103	LMN	Suspected	Zidovudine, Lamivudine, Abacavir, IVIg	46, alive	Stable
Verma A & Mishra SK, 2006
Patient #1	57/M	37	618	Not detected	UMN	Definite	Zidovudine, Lamivudine Lopinavir, Ritonavir, Tenofovir Zidovudine,	36, alive	Stable
Patient #2	42/M	146	219	32.2 × 103	UMN	Definite	Lamivudine, Infuvirtide, Ritonavir, Tenofovir Lamivudine,	42, alive	Stable
Orsini et al, 2012	56/M	Newly discovered	300	698	LMN	Suspected	Stavudine, Nevirapine, IVIg,	48, alive	Progressive
Almeida et al, 2010	59/M	60	473	Not detected	UMN	Suspected	Not reported	36,alive	Progressive
Calza et al, 2004	60/M	108	579	3100	UMN + LMN	Definite	Zidovudine, Didanosine, Nelfinavir, Riluzole	36, died	initial improvement then progressive

^*article not found, case of HALS in table from Verma et al, 2006.