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. 2013 Jul 25;8(7):e69129. doi: 10.1371/journal.pone.0069129

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© 2013 Yang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Latency to find the platform during the training was reported as mean ±S.E.M. Each point represented the mean daily values of four trials per day. The latency of the group with systemic transplantation of UC-MSCs educated CD4⁺CD25⁺ T regulatory cells was significantly lower than the group receiving vehicle after the last 3 days of training. *p＜0.05.

B&C The bar graphs showed the number of platform location cross (B) and the time in the target section (C) during the probe trial within 60s were significantly improved in the group with systemic transplantation of UC-MSCs educated CD4⁺CD25⁺ T regulatory cells. Data are reported as mean ±S.E.M. **p<0.01.

D & E Representative visible learning curve of transgenic mice with transplantation of UC-MSCs educated CD4⁺CD25⁺ T regulatory cells (D) and PBS (E) at day 5 of first training.