Fig. 7.

Schematic of the data interpretation. (A) In the presence of GluR agonists, extracellular Ca²⁺ can enter neurons through the channels of NMDARs and Ca²⁺-permeable channels of GluA2-lacking AMPARs. (B) Ifenprodil by inhibiting GluN1/GluN2B prevents Ca²⁺ entry through these particular NMDARs. Ca²⁺, therefore, may enter the cytoplasm through the channels of GluN1/GluN2A only. IEM-1460 by blocking the Ca²⁺ permeable channels of AMPARs abolishes Ca²⁺ signals in neurons expressing GluA2-lacking AMPARs. Detailed description of data interpretation is presented in the section 4.4.