Table 3.
Prevalence ratios of reduced GFR comparing NHANES 1999–2002 with NHANES 1988–1994
| PR (95% CI) | P-value | |
|---|---|---|
| eGFRcr < 60 mL/min/1.73 m2 | ||
| Unadjusted | 1.39 (1.19, 1.62) | <0.001 |
| Adjusted for age | 1.31 (1.16, 1.53) | <0.001 |
| + sex & race | 1.32 (1.16, 1.54) | <0.001 |
| + diagnosed DM & HTN | 1.24 (1.09, 1.45) | 0.002 |
| + above + BMI† | 1.24 (1.09, 1.45) | 0.002 |
| eGFRcys < 60 mL/min/1.73 m2 | ||
| Unadjusted | 1.57 (1.26, 1.96) | <0.001 |
| Adjusted for age | 1.46 (1.25, 1.83) | <0.001 |
| + sex & race | 1.47 (1.25, 1.83) | <0.001 |
| + diagnosed DM & HTN | 1.38 (1.17, 1.72) | <0.001 |
| + above + BMI† | 1.34 (1.15, 1.67) | <0.001 |
| eGFRcr-cys < 60mL/min/1.73 m2 | ||
| Unadjusted | 1.59 (1.28, 1.96) | <0.001 |
| Adjusted for age | 1.48 (1.30, 1.83) | <0.001 |
| + sex & race | 1.49 (1.30, 1.84) | <0.001 |
| + diagnosed DM & HTN | 1.37 (1.20, 1.70) | <0.001 |
| + above + BMI† | 1.33 (1.17, 1.65) | <0.001 |
Note: NHANES 1988–1994 is the reference group. All models (unadjusted and adjusted) are composed of the same subsample with available cystatin C. Potential mediators are added sequentially; in other words, “+ above + BMI” indicates adjustment for age, sex and race, diagnosed DM and HTN, and BMI.
BMI was modeled as an ordinal variable: 1 = BMI 0–24.9 kg/m2, 2 = BMI 25–29.9 kg/m2, 3 = BMI ≥30 kg/m2
PR, prevalence ratio; DM, diabetes mellitus; HTN, hypertension; CI, confidence interval; NHANES, National Health and Nutrition Examination Survey; GFR, glomerular filtration rate ; eGFR, estimated GFR; eGFRcr, eGFR based on serum creatinine; eGFRcys, eGFR based on serumcystatin C; eGFRcr-cys, eGFR based on serum creatinine and cystatin C;