Table 1.
The severity of RA histology in tissue sections of control and CIA mice
| |
|
Shoulder joint |
Elbow joint |
Knee joint |
Ankle joint |
||||
|---|---|---|---|---|---|---|---|---|---|
| L | R | L | R | L | R | L | R | ||
| |
Control mice |
||||||||
|
Mouse 1 |
inflammation |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
| synovial hyperplasia |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
| pannus formation |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
| bone/cartilage loss |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
| |
Score |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
|
Mouse 2 |
inflammation |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
| synovial hyperplasia |
1 |
1 |
1 |
1 |
1 |
0 |
1 |
0 |
|
| pannus formation |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
| bone/cartilage loss |
1 |
1 |
1 |
1 |
0 |
0 |
0 |
0 |
|
| |
Score |
4 |
2 |
2 |
3 |
1 |
0 |
1 |
0 |
|
Mouse 3 |
nd |
|
|
|
|
|
|
|
|
| |
CIA mice |
||||||||
|
Mouse 1 |
inflammation |
0 |
2 |
3 |
2 |
2 |
3 |
3 |
3 |
| synovial hyperplasia |
1 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
|
| pannus formation |
0 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
|
| bone/cartilage loss |
0 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
|
| |
Score |
1 |
11 |
12 |
8 |
11 |
12 |
12 |
12 |
|
Mouse 2 |
inflammation |
0 |
3 |
1 |
1 |
3 |
3 |
2 |
3 |
| synovial hyperplasia |
0 |
3 |
2 |
2 |
3 |
3 |
2 |
3 |
|
| Pannus formation |
0 |
3 |
2 |
2 |
3 |
3 |
2 |
3 |
|
| bone/cartilage loss |
1 |
2 |
1 |
2 |
3 |
3 |
2 |
3 |
|
| |
Score |
1 |
11 |
6 |
7 |
12 |
12 |
8 |
12 |
|
Mouse 3 |
inflammation |
2 |
3 |
1 |
2 |
2 |
2 |
1 |
2 |
| synovial hyperplasia |
1 |
3 |
1 |
3 |
3 |
3 |
2 |
3 |
|
| pannus formation |
2 |
3 |
1 |
3 |
3 |
3 |
1 |
3 |
|
| bone/cartilage loss |
2 |
3 |
1 |
3 |
3 |
3 |
1 |
3 |
|
| |
Score |
7 |
12 |
4 |
11 |
11 |
11 |
5 |
11 |
|
Mouse 4 |
inflammation |
3 |
3 |
3 |
2 |
3 |
2 |
3 |
3 |
| synovial hyperplasia |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
|
| pannus formation |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
|
| bone/cartilage loss |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
|
| |
Score |
12 |
12 |
12 |
10 |
12 |
11 |
12 |
12 |
|
Mouse 5 |
inflammation |
3 |
3 |
3 |
1 |
3 |
3 |
2 |
nd |
| synovial hyperplasia |
2 |
3 |
3 |
1 |
3 |
3 |
3 |
nd |
|
| pannus formation |
2 |
3 |
3 |
1 |
3 |
3 |
2 |
nd |
|
| bone/cartilage loss |
1 |
3 |
2 |
1 |
2 |
3 |
2 |
nd |
|
| |
Score |
8 |
12 |
11 |
4 |
11 |
12 |
9 |
nd |
| Mouse 6 | nd | ||||||||
Scoring for the severity of the joint lesions into four grades was assessed as follows: grade 0, normal; grade 1, slight; grade 2, moderate; grade 3, severe.
nd = not done.