Table 1.
Associations of HLA supertypes and their component alleles with HCV viremia among HCV seropositive women - shown are those HLA supertypes that retained significant or marginally significant (α < 0.10) false discovery rate (FDR)-adjusted q values after adjustement for multiple comparisions
| HLA supertype 1,2,3,4 | HCV RNA positive (N=622) |
HCV RNA negative (N=136) |
PR (95% CI) | Unad justed p value |
False discovery rate (FDR)- adjusted q value |
Permutation resampling- adjusted p value |
|---|---|---|---|---|---|---|
| DRB3 supertype | 176 (32%) | 14 (12%) | 0.35 (0.20, 0.59) | 0.000 | 0.008 | 0.000 |
| DRB1*03:01 | 99 (18%) | 8 (7%) | 0.38 (0.19, 0.75) | 0.005 | ||
| DRB1*13:02 | 87 (16%) | 6 (5%) | 0.35 (0.16, 0.77) | 0.009 | ||
| DR8 supertype | 47 (8%) | 17 (15%) | 1.84 (1.19, 2.85) | 0.007 | 0.080 | 0.917 |
| DRB1*08:01 | 3 (1%) | 3 (3%) | 2.89 (1.17, 7.13) | 0.021 | ||
| DRB1*08:02 | 3 (1%) | 3 (3%) | 2.56 (1.20, 5.47) | 0.015 | ||
| DRB1*08:04 | 36 (6%) | 9 (8%) | 1.36 (0.74, 2.50) | 0.324 | ||
| DRB1*08:06 | 5 (1%) | 2 (2%) | 2.14 (0.65, 7.07) | 0.214 | ||
| DR1*01 supertype | 52 (9%) | 21 (18%) | 1.70 (1.14, 2.56) | 0.010 | 0.098 | 0.336 |
| DRB1*01:01 | 41 (7%) | 17 (15%) | 1.74 (1.12, 2.68) | 0.013 | ||
| DRB1*01:03 | 3 (1%) | 0 | 5 | 5 | ||
| DRB1*10:01 | 9 (2%) | 5 (4%) | 1.96 (0.98, 3.95) | 0.058 | ||
| A supertype | 132 (24%) | 44 (38%) | 1.64 (1.18, 2.29) | 0.004 | 0.080 | 0.115 |
| DRB1*01:01 | 41 (7%) | 17 (15%) | 1.74 (1.12, 2.68) | 0.013 | ||
| DRB1*01:02 | 33 (6%) | 9 (8%) | 1.38 (0.76, 2.50) | 0.296 | ||
| DRB1*04:01 | 29 (5%) | 6 (5%) | 0.93 (0.44, 1.95) | 0.844 | ||
| DRB1*04:04 | 20 (4%) | 5 (4%) | 0.92 (0.41, 2.07) | 0.850 | ||
| DRB1*04:05 | 10 (2%) | 5 (4%) | 2.05 (1.01, 4.17) | 0.048 | ||
| DRB1*04:08 | 1 (0%) | 0 | e | e | ||
| DRB1*10:01 | 9 (2%) | 5 (4%) | 1.96 (0.98, 3.95) | 0.058 | ||
| DRB1*14:02 | 1 (0%) | 1 (1%) | 1.91 (0.46, 7.83) | 0.370 |
PR: Prevalence Ratio; 95% CI: 95% Confidence Interval
Supertypes were defined as in prior studies by Greenbaum et al.14 (DRB3 supertype), Lund et al.15 (DR8 supertype), Neilson et al.16 (DRB1*01 supertype), and Ou et al.17 (A supertype)
Percentages relect the number of women who were homozygous or heterozygous for the indicated supertype or genotype amongst those with complete DRB1 genotype information (N=675)
Analyses were conducted using log-binomial models with adjustment for race/ethnicity (non-Hispanic Black, non-Hispanic White, Hispanic)
Associations of HLA supertypes that did not show significant or marginally significant associations after adjustment for multiple comparisons are shown in Supplementary Table 1
No estimate due to model non-convergence