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. 2013 Jul 25;8(7):e68940. doi: 10.1371/journal.pone.0068940

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© 2013 Joice, Lipsitch

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a, SIS model with a proportion of the population vaccinated and initially susceptible () and unvaccinated and initially susceptible (), who can get infected with either the drug-sensitive strain ( subscript), –resistant strain ( subscript), or both ( subscript) strains. Plots depict model state at equilibrium (all drug-resistant, all drug-sensitive, stable co-existence of both strains, or elimination of all strains) across a range of overall vaccine efficacy () and additional vaccine efficacy against resistant strain (), where vaccine coverage is 80%. Plots show situation with no fitness cost (b) and with 8% fitness cost (c). Color scheme throughout the paper is as follows: uninfected (gray), sensitive (blue), resistant (red), co-infected with both strains/coexistence of both strains (purple). This model corresponds to Model E of Ref [11].

Inline graphic — a, SIS model with a proportion of the population vaccinated and initially susceptible () and unvaccinated and initially susceptible (), who can get infected with either the drug-sensitive strain ( subscript), –resistant strain ( subscript), or both ( subscript) strains. Plots depict model state at equilibrium (all drug-resistant, all drug-sensitive, stable co-existence of both strains, or elimination of all strains) across a range of overall vaccine efficacy () and additional vaccine efficacy against resistant strain (), where vaccine coverage is 80%. Plots show situation with no fitness cost (b) and with 8% fitness cost (c). Color scheme throughout the paper is as follows: uninfected (gray), sensitive (blue), resistant (red), co-infected with both strains/coexistence of both strains (purple). This model corresponds to Model E of Ref [11].