Table 2. Hazard ratios for cardiovascular diseases according to quartiles of 25(OH)D.
| 25(OH)D quartile |
Cases
|
Model 1
|
Model 2
|
|||||
|---|---|---|---|---|---|---|---|---|
| (Median nmol/L)* | N | (%) | HR | 95% CI | P trend† | HR | 95% CI | P trend† |
| Myocardial Infarction | ||||||||
| Q4 (66.5) | 118 | (21.1) | 1.0 | (Referent) | 1.0 | (Referent) | ||
| Q3 (50.5) | 117 | (20.9) | 0.95 | (0.70-1.28) | 0.85 | (0.62-1.17) | ||
| Q2 (40.4) | 158 | (28.3) | 1.24 | (0.93-1.66) | 1.07 | (0.78-1.45) | ||
| Q1 (28.9) | 166 | (29.7) | 1.43 | (1.07-1.92) | <0.01 | 1.17 | (0.86-1.58) | 0.19 |
| Stroke | ||||||||
| Q4 (66.6) | 111 | (23.6) | 1.0 | (Referent) | 1.0 | (Referent) | ||
| Q3 (50.5) | 101 | (21.4) | 0.86 | (0.63-1.17) | 0.83 | (0.60-1.13) | ||
| Q2 (40.4) | 102 | (21.7) | 0.83 | (0.61-1.12) | 0.83 | (0.61-1.14) | ||
| Q1 (28.9) | 157 | (33.3) | 1.37 | (1.02-1.84) | 0.05 | 1.25 | (0.92-1.70) | 0.19 |
| CVD as composite endpoint | ||||||||
| Q4 (66.6) | 229 | (22.2) | 1.0 | (Referent) | 1.0 | (Referent) | ||
| Q3 (50.5) | 218 | (21.2) | 0.89 | (0.70-1.14) | 0.84 | (0.65-1.09) | ||
| Q2 (40.4) | 260 | (25.2) | 1.06 | (0.83-1.35) | 0.96 | (0.75-1.24) | ||
| Q1 (28.9) | 323 | (31.4) | 1.41 | (1.11-1.79) | <0.01 | 1.19 | (0.93-1.52) | 0.12 |
Hazard Ratios calculated by Cox regression analyses using Prentice weights to account for the case-cohort design;
Model 1 adjusted for BMI and sex, stratified by center and age at baseline;
Model 2 additionally adjusted for waist circumference, alcohol intake, education level, physical activity, and smoking
*
Quartile medians from the subcohort;
†
P for trend calculated modeling quartile medians as continuous variable;