Table 3. Hazard ratios for cardiovascular diseases according to clinical vitamin D status categories.

Clinical category	25(OH)D (nmol/L)	N cases/subco.	Model 1			Model2
			HR	95% CI	P	HR	95% CI	P
Myocardial Infarction
Sufficiency	≥50	183/802	1.0	(Referent)
Mild deficiency	25-49.9	315/1162	1.24	(0.99-1.55)	0.06	1.10	(0.87-1.39)	0.43
Moderate to severe deficiency	<25	61/168	1.81	(1.25-2.64)	<0.01	1.56	(1.08-2.25)	0.02
Stroke
Sufficiency	≥50	171/802	1.0	(Referent)
Mild deficiency	25-49.9	240/1162	0.99	(0.79-1.24)	0.93	0.95	(0.75-1.19)	0.65
Moderate to severe deficiency	<25	60/168	1.81	(1.25-2.62)	<0.01	1.54	(1.05-2.27)	0.03
CVD (composite)
Sufficiency	≥50	354/802	1.0	(Referent)		1.0	(Referent)
Mild deficiency	25-49.9	555/1162	1.11	(0.93-1.33)	0.25	1.01	(0.84-1.22)	0.90
Moderate to severe deficiency	<25	121/168	1.80	(1.33-2.45)	<0.01	1.53	(1.12-2.09)	<0.01

Hazard ratios calculated by Cox regression analyses using Prentice weights to account for the case-cohort design;

Model 1 adjusted for BMI and sex, stratified by center and age at baseline;

Model 2 additionally adjusted for waist circumference, alcohol intake, education level, physical activity, and smoking