Table 1. Qualitative Distribution of PLAP+ Cells in Sensory, Nonsensory, and Neuronal Regions of the P6 Mouse Inner Ear Injected with BOLAP Retroviral Lineage Vector at E11.5.
Region | Location§ | P6 Inner Ear Specimen Identityδ | |||||
HJ- 5 | HJ- 6 | HJ- 8 | HJ- 9 | HJ- 11 | HJ- 12 | ||
Sensory | Posterior crista | √ | √ | √ | √ | √ | √ |
Organ of Cortiψ | √ | √ | √ | √ | √ | ||
Anterior crista | √ | ||||||
Lateral crista | √ | ||||||
Utricular macula | √ | ||||||
Saccular macula | √ | ||||||
Nonsensory | Posterior crista | √ | √ | √ | √ | √ | |
Spiral limbus | √ | √ | √ | √ | √ | ||
Stria vascularis | √ | √ | √ | √ | |||
Reissner's membrane | √ | √ | √ | √ | |||
Spiral ligament | √ | √ | √ | ||||
Saccule | √ | √ | |||||
Anterior crista | √ | √ | |||||
Utricle | √ | √ | |||||
Lateral crista | √ | ||||||
Neuronal | Auditory ganglion and nerve | √ | √ | √ | √ | √ | |
Vestibular ganglion and nerve | √ | √ | √ | √ |
defined by microscopic evaluation of serial 14 µm cryostat sections.
two or more PLAP+ cells in a location earned a positive score (checkmark). HJ are author initials followed by the unique specimen identification code.
PLAP+-cells were most frequently detected in the base and middle turn of the cochlea and rarely in the apex.