Figure 1. Schematic of
signalling in ASMC.
Agonist stimulation of G-protein coupled receptors (GPCR) induces PLC
activation, giving rise to 
production and 
entry through receptor-operated 
channels (ROCC). 
triggers 
release through IPR. Depletion of the SR from 
causes STIM protein oligomerisation and migration toward the cell membrane, where they bind and activate store-operated 
channels (SOCC). 
ATP-ases pump 
back into the SR (SERCA) and out of the cell (PMCA).