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. 2013 Jul 25;8(7):e69598. doi: 10.1371/journal.pone.0069598

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© 2013 Croisier et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — (A) Fluorescence imaging of in ASMC of a mouse lung slice treated with agonist and CPA. Agonist removal leads to decrease. (B–D) Model simulations of the experiments shown in (A), assuming that (B) CPA quickly blocks the SERCA, (C) CPA slowly blocks the SERCA, (D) CPA partially blocks the SERCA but reaches maximum strength rather quickly. Black solid and dashed curves (left y-axis) represent respectively and ; blue and red curves (right y-axis) show respectively the fraction of open SOCC and the fraction of operating SERCA (that is, , where is given by Eq. (0c)).

(A) Fluorescence imaging of in ASMC of a mouse lung slice treated with agonist and CPA. Agonist removal leads to decrease. (B–D) Model simulations of the experiments shown in (A), assuming that (B) CPA quickly blocks the SERCA, (C) CPA slowly blocks the SERCA, (D) CPA partially blocks the SERCA but reaches maximum strength rather quickly. Black solid and dashed curves (left y-axis) represent respectively and ; blue and red curves (right y-axis) show respectively the fraction of open SOCC and the fraction of operating SERCA (that is, , where is given by Eq. (0c)).