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. 2013 Jul 25;8(7):e69598. doi: 10.1371/journal.pone.0069598

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© 2013 Croisier et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Tests of the model predictions shown in Fig. 6B–D, performed with mouse lung slices. (A) Significantly longer exposure to agonist+CPA and to CPA than in Fig. 6A still fails to maintain SOCE. (B) Same experiment as in (A) except that extracellular is removed before agonist is applied a second time, confirming the residual presence of in the SR and hence the partial efficacy of CPA to inhibit SERCA (scenario of Fig. 6D). (Insets show magnifications of selected time windows).

Inline graphic — Tests of the model predictions shown in Fig. 6B–D, performed with mouse lung slices. (A) Significantly longer exposure to agonist+CPA and to CPA than in Fig. 6A still fails to maintain SOCE. (B) Same experiment as in (A) except that extracellular is removed before agonist is applied a second time, confirming the residual presence of in the SR and hence the partial efficacy of CPA to inhibit SERCA (scenario of Fig. 6D). (Insets show magnifications of selected time windows).