Table 1. Parameter values used in the model.

Parameter	symbol	value	units	reference
PMCA maximum flux	Vp	7.5	μM/s	this work
PMCA affinity	Kp	1.5	μM	0.1–1 [59]
SOCE maximum flux	Vs	1.57	μM/s	this work
STIM SR Ca2+ affinity	Ks	50	μM	c* s/2
SOCE Hill exponent	ns	4		[33]
SOCE timescale	τs	30	s	[32]
Constant leak influx	α0	0	μM/s	Vs
Cyt/SR vol. × buffer effects	γ	5.405		[34], [60]
ROCE rate	α1	0.00105	s−1	this work
SERCA maximum flux	Ve	5	μM/s	this work
SERCA affinity	Ke	0.1	μM	0.1–1 [61]
CPA effect timescale	τe	30	s	∼ min
IPR rate	kIPR	0.667	s−1	this work
Agonist concentration		1	μM	this work
Agonist effect timescale	τp	30	s	∼ min
SR leak rate	JSR	0.01	s−1	kIPR
RyR leak rate (Rya-Caf effect)	KRYR	0.19	s−2	this work
Rya-Caf effect timescale	τSR	10	s	∼ min
IPR affinity for	K1	0.138	μM	[34]
IPR affinity for Ca2+ (inhib. site)	K2	1.05	μM	[34]
IPR affinity for IP3	K3	0.943	μM	[34]
IPR affinity for Ca2+ (inhib. site)	K4	0.144	μM	[34]
IPR affinity for Ca2+ (activ. site)	K5	0.082	μM	[34]
IPR Ca2+ dissoc. rate (inhib. site)	k−2	0.167	s−1	this work
IPR Ca2+ dissoc. rate (inhib. site)	k−4	0.138 k−2	s−1	[34]

For and , the equilibrium concentrations are nM and M, which are in the physiological ranges [40], [41].