Figure 1.

Overall structure of the Pla protein, oriented perpendicular to the membrane plane, exracellular side up. The peptide chain is shown as white strands, and the extracellular loops are colored (L1–L5). The yellow spheres show positions of the active site residues (named) and the white spheres locate conserved residues at the bottom of the active site. On the right side of the image, LPS and the amino acids that contact it are shown in stick models (gray and black, respectively). The figure is modified from the crystal structure of Pla (Eren et al., 2010; Eren and van den Berg, 2012).