Figure 5.

Evaluation of the drug-independence of the CVS model developed. Six different compounds, prazosin, HCTZ, propranolol, fasudil, enalapril and amlodipine, were used to estimate the system parameters of the CVS model. To determine if the system parameters were truly drug-independent, the model was re-evaluated after omitting the different compounds one by one. The continuous black lines represent the parameter estimates of the model including all compounds and the dashed lines represent the 90% CIs around these parameter estimates. The black lines with a black dot and the grey boxes represent the parameter estimates and the 90% CIs around these parameter estimates after omission of one of the compounds. When the grey boxes overlap with the area between the dotted lines, parameters are not significantly different and the model is independent of that compound. Therefore, the parameter estimate of FB1 is dependent on the presence of the amlodipine data.