Figure 6.

System properties of the CVS. The system properties of the CVS were investigated by simulating the effects on CO, TPR and MAP after stimulating TPR (upper panel) or inhibiting CO (lower panel). Both perturbations result in visually comparable effects on CO and TPR (A). However, the response of the MAP is in the opposite direction (B) indicating that the model can be used to identify the site of action. In addition, the hysteresis plot shows that an effect on TPR results in an immediate effect on CO as a result of feedback, whereas, an effect on CO results in a delayed response of TPR as a result of feedback (plot C).