Table 2.

Study overview

Study	Measures	Study designs	Compound	Dose	Number of rats
1 Multiple dosing study	MAP	Days −1–0 : baseline (not included in analysis) Day 1 : baseline Days 2–3 : vehicle Days 4–9 : active treatment (once daily) Days 10–15: washout	Enalapril	30 mg·kg−1 p.o	5
			Fasudil	30 mg·kg−1 p.o	5
			Amlodipine	10 mg·kg−1 p.o	5
			Propranolol	1 mg·mL−1 in drinking water	5
2 Single administrations of different doses on separate days	MAP, CO (and TPR)	Day 1: vehicle Days 2–5: a different dose each day	Amlodipine	0.3, 1, 3, 10 mg·kg−1 p.o.	2
			Prazosin	0.04, 0.2, 1, and 5 mg·kg−1 p.o.	2
			HCTZ	0.1, 0.3, 1, 3 mg·kg−1 p.o.	2