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. 2013 Jul 26;4:213. doi: 10.3389/fmicb.2013.00212

FIGURE 1.

FIGURE 1

Currently explored approaches aiming at developing new animal models for the study of hepatitis C virus infection. From left to right: xenotransplantation of human cells, genetic humanization by expression of defined human specific factors, viral adaptation of HCV to mouse cells. HLA transgenic mice can be crossed with the different models in order to improve immune responses.