Figure 2.

Prostate cancer gene fusion classification. The ongoing effort to screen prostate cancer patients for gene fusions, in combination with the recent technology advances, has resulted in comprehensive gene fusion landscape. This schematic highlights gene fusions categorized into ETS rearrangements and RAF kinase gene fusions. A number of rare gene fusions that occur at less than 1% frequency have been excluded. Two other non-fusion classes that are characterized by mutual exclusivity with ETS rearrangements SPINK1 and SPOP mutations. The percentages highlight the estimated frequency of each gene fusion based on published screens.