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. Author manuscript; available in PMC: 2013 Jul 26.
Published in final edited form as: Hum Genet. 2010 Mar 30;127(6):659–668. doi: 10.1007/s00439-010-0811-x

Table 4.

Optimal design options for OR = 5

Design parameters Design-1 Design-2
Prob carrier, controls 0.01 0.05
Total N 1,058 274
Powerconditional 0.98 0.99
Powerunconditional 0.90 0.90
Stage-1 cases (nd,1) 144 37
Stage-1 threshold (t) 4 5
P(stop|null) 0.94 0.96
P(stop|alt) 0.08 0.09
E[N|null] 196.48 45.52
E[N|alt] 984.24 252.48