. Author manuscript; available in PMC: 2013 Jul 26.

Published in final edited form as: Basic Res Cardiol. 2012 Mar 31;107(3):264. doi: 10.1007/s00395-012-0264-6

Table 1.

Hemodynamic, cardiac and blood gas parameters during variable coronary perfusion pressures with and without 4AP or Diltiazem

CPP	140	130	120	110	100	90	80	70	60	50	40
	Baseline
Systolic blood pressure (mmHg)
Control	134 ± 9	133 ± 9	132 ± 8	132 ± 8	132 ± 8	131 ± 8	130 ± 8	129 ± 8	128 ± 8	125 ± 7	119 ± 6
4AP	132 ± 9	134 ± 9	134 ± 9	130 ± 10	133 ± 10	131 ± 11	128 ± 11	128 ± 12	125 ± 11	120 ± 9	115 ± 8
Diltiazem	103 ± 8^*,^†	100 ± 8^*,^†	99 ± 8^*,^†	97 ± 7^*,^†	95 ± 7^*,^†	97 ± 8^*,^†	97 ± 9^*,^†	95 ± 9^*,^†	93 ± 8^*,^†	93 ± 9^*,^†	82 ± 6^*,^†
Diastolic blood pressure (mmHg)
Control	83 ± 6	82 ± 6	82 ± 7	82 ± 7	82 ± 7	81 ± 7	81 ± 7	81 ± 6	80 ± 6	81 ± 5	78 ± 5
4AP	77 ± 4	77 ± 5	84 ± 5	79 ± 4	S3 ± 5	80 ± 5	79 ± 5	79 ± 6	76 ± 5	76 ± 4	74 ± 4
Diltiazem	69 ± 5	66 ± 5	66 ± 5^†	65 ± 4^*,^†	63 ± 4^*,^†	63 ± 4^*,^†	63 ± 4^*,^†	62 ± 4^*,^†	61 ± 4^*,^†	60 ± 4^*,^†	54 ± 4^*,^†
Mean aortic pressure (mmHg)
Control	108 ± 8	107 ± 8	106 ± 7	106 ± 7	106 ± 7	105 ± 7	105 ± 7	104 ± 7	103 ± 6	102 ± 6	97 ± 5
4AP	101 ± 5	104 ± 7	107 ± 6	104 ± 7	106 ± 7	104 ± 7	102 ± 8	101 ± 8	98 ± 7	96 ± 6	93 ± 6
Diltiazem	86 ± 6^*	83 ± 7^*,^†	82 ± 6^*,^†	81 ± 6^*,^†	79 ± 5^*,^†	80 ± 6^*,^†	80 ± 6^*,^†	78 ± 6^*,^†	76 ± 6^*,^†	76 ± 7^*,^†	74 ± 7^*,^†
Heart Rate (beats/min)
Control	50 ± 5	51 ± 5	51 ± 6	51 ± 6	52 ± 6	53 ± 7	61 ± 12	53 ± 7	53 ± 7	56 ± 6	61 ± 5
4AP	49 ± 7	46 ± 7	46 ± 6	48 ± 7	48 ± 6	49 ± 7	48 ± 7^*	48 ± 7	48 ± 7	49 ± 6	52 ± 6^*
Diltiazem	79 ± 8^*,^†	80 ± 7^*,^†	80 ± 6^*,^†	81 ± 6^*,^†	81 ± 7^*,^†	77 ± 6^*,^†	76 ± 6^*,^†	77 ± 6^*,^†	79 ± 6^*,^†	76 ± 6^*,^†	81 ± 6^*,^†
Coronary blood flow (ml/min/g)
Control	0.76 ± 0.05	0.64 ± 0.04	0.58 ± 0.03	0.53 ± 0.03	0.50 ± 0.03	0.48 ± 0.03	0.45 ± 0.03	0.43 ± 0.03	0.39 ± 0.03	0.32 ± 0.04	0.23 ± 0.04
4AP	0.55 ± 0.03^*	0.43 ± 0.03^*	0.44 ± 0.04^*	0.43 ± 0.03^*	0.39 ± 0.04^*	0.38 ± 0.05^*	0.37 ± 0.05^*	0.34 ± 0.04^*	0.31 ± 0.03^*	0.26 ± 0.02^*	0.17 ± 0.03^*
Diltiazem	1.48 ± 0.18^*,^†	1.30 ± 0.12^*,^†	1.15 ± 0.09^*,^†	0.99 ± 0.08^*,^†	0.86 ± 0.06^*,^†	0.70 ± 0.05^*,^†	0.60 ± 0.03^†	0.51 ± 0.03^†	0.44 ± 0.03	0.37 ± 0.03	0.22 ± 0.03
Myocardial oxygen consumption (μl O₂/min/g)
Control	69 ± 8	68 ± 8	66 ± 8	64 ± 7	64 ± 7	60 ± 7	58 ± 6	56 ± 6	51 ± 5	44 ± 5	32 ± 5
4AP	59 ± 5^*	54 ± 4^*	51 ± 5^*	52 ± 5^*	48 ± 4^*	48 ± 6^*	47 ± 6^*	44 ± 5^*	41 ± 4^*	34 ± 3^*	26 ± 4
Diltiazem	72 ± 17	68 ± 16	63 ± 16	64 ± 13	62 ± 11	56 ± 9	53 ± 7	50 ± 7	50 ± 6	40 ± 7	28 ± 5
Coronary venous PO₂
Control	27 ± 3.0	24 ± 2.3	21 ± 2.3	19 ± 2.6	18 ± 2.0	18 ± 2.0	17 ± 2.0	17 ± 1.2	16 ± 1.3	15 ± 0.7	15 ± 1.0
4AP	23 ± 2.2^*	22 ± 1.7	21 ± 1.9	21 ± 1.5	19 ± 1.3	19 ± 1.4	19 ± 1.3	18 ± 1.5	17 ± 1.1	14 ± 0.9	14 ± 0.9
Diltiazem	44 ± 5.3^*,^†	42 ± 5.3^*,^†	40 ± 5.1^*,^†	37 ± 4.5^*,^†	33 ± 3.9^*,^†	31 ± 3.0^*,^†	29 ± 2.6^*,^†	26 ± 1.7^*,^†	24 ± 1.6^*,^†	21 ± 1.0^†	19 ± 1.2
dP/dT Max (mmHg/s)
Control	1,501 ± 114	1,501 ± 115	1,527 ± 121	1,532 ± 115	1,569 ± 113	1,551 ± 111	1,561 ± 106	1,559 ± 111	1,534 ± 1115	1,393 ± 130	1,135 ± 99
4AP	1,362 ± 115	1,334 ± 121^*	1,351 ± 128^*	1,349 ± 125^*	1,258 ± 127^*	1,254 ± 110^*	1,228 ± 123^*	1,242 ± 127^*	1,200 ± 127^*	1,144 ± 135^*	999 ± 82
Diltiazem	1,476 ± 239	1,491 ± 264	1,473 ± 265	1,477 ± 270	1,454 ± 251	1,456 ± 265	1,425 ± 270	1,426 ± 293	1,389 ± 279	1,365 ± 267	1,065 ± 130
dP/dT Min (mmHg/s)
Control	−1,448 ± 159	−1,455 ± 148	−1,429 ± 148	−1,359 ± 167	−1,359 ± 150	−1,338 ± 137	−1,306 ± 130	−1,276 ± 127	−1,136 ± 134	−1,016 ± 155	−922 ± 146
4AP	−1,177 ± 132^*	−1,148 ± 135^*	−1,129 ± 133^*	−1,086 ± 133^*	−1,124 ± 155^*	−1,079 ± 156^*	−1,058 ± 147^*	−1,058 ± 140^*	− 987 ± 131	− 879 ± 127	−744 ± 114
Diltiazem	−1,330 ± 117	−1,271 ± 110	−1,292 ± 116	−1,290 ± 125	−1,278 ± 127	−1,305 ± 156	−1,265 ± 171	−1,212 ± 154	−1,185 ± 139	−1,138 ± 169	−786 ± 165

Values are mean ± SE for Control, 4AP (n = 7), and diltiazem (n = 5)

P < 0.05 versus control same CPP;

^†

P < 0.05 versus 4AP same CPP