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Tri-layer constructs were responsive to various drugs. Rosiglitizone (Rosi), an activator of the adipogenic program, caused hyper-proliferation (bracket) at the basal layer of the epidermis at 9 days. TGF-β, also caused hyper-proliferation, to a lesser extent than the Rosi group, at the basal layer of the epidermis at 9 days. The adipose regions did not appear affected, morphologically, by the drug treatments. Images are representative of n=2 per group.
