Scheme 1.
The proposed scheme for activation of resting state P. aeruginosa-type CcP and the catalytic cycle for the reduction of hydrogen peroxide to two molecules of water. The G. sulfurreducens CcpA shows solution-based kinetic parameters that mimic the P. aeruginosa type of CcP. The second electron coupled step responsible for the continuation of the catalytic cycle is shown as a dotted arrow.