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Sequence discrimination in the minor groove. a, b Differences in the topology of the A-form dsRNA helix and the B-form dsDNA helix. Note especially the differences in the dimension and accessibility of the minor and major grooves. Chemical groups of an A–U pair (c) and a G–C pair (d) lying in the minor and major grooves. Discrimination in the minor groove relies on the appreciation of the chemical group in position 2 of purine rings
