Fig. 5.

Global view of the canonical RNA binding surface of dsRBDs. Region 1 (helix α1) and region 2 (loop 2) insert in two successive RNA minor grooves, region 3 (loop 4) contacts the phosphodiester backbone of the intervening RNA major groove. The residues shown in red sticks correspond to a the canonical KKxAK motif of the ADAR2 dsRBD1-RNA stem–loop complex (PDB code 2L3C) and b to the bipartite motif found in the RNase III–RNA complex (PDB code 2NUE) where one of the lysine is coming from helix α1. The numbering of the lysines corresponds to the sequences alignment of Fig. 1. See text for details