Fig. 7.

a Schematic representation of helix α1 showing the position of the residues involved in dsRNA binding. The numbers inside the circles correspond to the positions in the sequence alignment of Figs. 1, 7b. b Alignment of helix α1 sequences emphasizing the variability of the residues at positions 3, 4, 7 and 11, involved in RNA binding. c Schematic representation of helix α1 of ADAR2 dsRBD2 showing the location of the methionine making a sequence-specific contact to the H2 proton of an adenine. d Schematic representation of helix α1 of the dsRBD of Aa RNase III showing the location of the glutamine making a pair of sequence specific contact to the N3 and to the exocyclic amino group of a guanine